University of Tübingen Interfaculty Institute of Biochemistry - Feil group (signal transduction/transgenic models)

We study signal transduction in transgenic cell and mouse models by an approach that we call "in vivo biochemistry". To this end, we use state-of-the-art transgenic mouse technology and try to "watch" biochemical processes in real time in living cells, tissues and mice. Specifically, we are interested in the role of the signaling molecule cGMP in health and disease, with a current focus on cell growth and plasticity. The projects involve analyses at the whole organism, cellular and molecular level.