Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumorassociated carbohydrate antigens (TACAs). To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-driven Research scientist.
Research Scientist (m/f/d) Cellular Assay Development
The major focus of this position is the development of cellular assays which will be used for antibody characterization.
Your tasks and responsibilities:
- Development/establishment of in vitro cancer models (2D and 3D)
- Generation and characterization of stable knock-out cell lines (e.g. using CRISPR/Cas) and knock-in cell lines
- Design and performance of functional cellular assays to validate mAb candidates
- Developing and executing experiments to explore the activity and mode of action of mAb candidates
- Analysis of carbohydrate structures in the extracellular space
- Establishment, optimization, characterization, and validation of cell-based analytical methods
- Analysis and interpretation of data based on project needs (R, Prism, Python)
- Keep up to date on scientific advances in the field from literature and conferences
Your profile:
- PhD degree (obtained not later than 3 years ago) in Life Sciences with focus on immunology/cell biology/oncology
- Extensive hands-on experience in cell line engineering and flow cytometry is a must, hands-on experience in primary immune cell culture is an asset
- Significant experience in design, execution, and analysis of cell-based assays for proliferation, cell death and killing, adhesion, migration and other immune-oncological assays is desired
- Significant experience in 3D cell culture and extracellular vesicle isolation and analysis is a strong plus
- Data analytics skills using R or Python is a plus
- Ability to design and execute experiments, critically interpret experimental results, and present data in a meaningful manner
- A high level of communication in English and a work permit for Germany (for non-EU applicants) is mandatory
We Offer:
- A permanent position with a competitive salary as well as excellent opportunities for professional and personal development
- A diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamwork
- Annual bonus payment depending on the achievement of goals
- Regular company and team events
- Free “Jobticket” (allows the holder to use local public transport anywhere in the country)
Contact:
If you are self-driven, interested to work in a professional field at the forefront of science and your background and personal experience fit this profile, please send your application (including cover letter, CV, earliest possible starting date as well as salary expectations) in English or German via the application-button.