The overall focus of our lab is the intracellular sorting of membrane proteins and lipids, and the functional role of subcellular localization in the trafficking and metabolism of lipids. We are interested in particular how proteins and lipids are interacting to organize the
transport and metabolism of fatty acids during the biogenesis of lipid droplets.
http://www.klinikum.uni-heidelberg.de/JF.116338.0.html PhD Student Molecular Cell Biology
Activities and responsibilities
Our lab at the University of Heidelberg is seeking two highly motivated PhD candidates to address cutting-edge questions in organelle biology:
- PhD1: Investigate novel perilipin 3 interactions and their contribution to subcellular lipid droplet heterogeneity.
- PhD2: Elucidate the molecular mechanism of perilipin 3-mediated transcriptional regulation, and its connection to lipidomic flux and post-translational modifications.
Both projects employ state-of-the-art techniques, including proximity ligation assays, CRISPR/Cas9-mediated genome editing, metabolic labeling and RNA sequencing (RNA-seq).
Qualification profile
- Master’s degree (or equivalent) in Life Sciences or a related field.
- Proficiency in English (IELTS 6.5 or equivalent).
- A passion for scientific discovery, problem-solving, and teamwork.
We offer
- An opportunity to contribute to pioneering research at the forefront of organelle biology.
- A stimulating, international, and diverse research environment.
- Fully funded 4-year PhD positions (65% TV-L, based on collective wage agreements).
- Dedicated supervision and mentoring, including Thesis Advisory Committee meetings.
- Integration into the Graduate School HBIGS and collaboration within the Lipid Droplet Research Unit FOR5815.
- Professional and personal development opportunities through workshops, seminars, and networking events.
- The University of Heidelberg is a leading institution in research and education, located in one of Europe’s most vibrant scientific communities.