PhD Student (gn*) Biological Sciences

Fixed-term of 3 years | Part-time witch 65 % | Salary according to TV-L E13 | Institute for Experimental Pathology | Job ID: 10520

We are UKM. We have a clear social mission and, with our focus on healthcare, research, and teaching, we bear a unique responsibility.

To meet our high standards every day, we are looking forward to your scientific expertise at the Institute for Experimental Pathology based at the Center for Inflammation Research at the University of Münster - ideally with you on board!

PROECT TITLE:

Altered production, dynamics, and function of neutrophils are hallmarks of inflammageing

THE INSTITUTE AND PROJECT:

The Institute for Experimental Pathology is led by Oliver Soehnlein. His work focuses on the importance of neutrophils in acute and chronic inflammation (Soehnlein et al., Sci Transl Med, 2011; Ferraro et al., JACC, 2019; Silvestre-Roig et al., Nature, 2019; Schumski et al., Circulation, 2021). Central to the group's mechanistic understanding of how neutrophils promote chronic, sterile inflammation is its interplay with antigen presenting cells, predominantly macrophages (Soehnlein & Lindbom, Nat Rev Immunol, 2010; Soehnlein et al., Nat Rev Immunol, 2017; Soehnlein & Libby, Nat Rev Drug Discov, 2021). It is a key feature of the group's work to unveil thus far unknown mechanistic details which are then translated towards innovative preclinical intervention strategies (Alard et al., Sci Transl Med, 2015; Silvestre-Roig et al., Nature, 2019), some of which have been patented. In this project, altered mechanisms of granulopoiesis and dysregulated neutrophil functions in ageing will be investigated. Our group is highly interdisciplinary, international, and uses state-of-the-art techniques spanning a broad range from immunology, cell and molecular biology, (spatial) single cell omics and bioinformatics. The project is embedded in national and international consortia on neutrophils and inflammation and funded by the Else Kröner-Fresenius Stiftung.

Your Tasks

Design and conduct experiments utilizing state-of-the-art approaches such as:
Animal models of neutrophil biology and ageing
- Flow cytometric analysis of immune cell populations from murine tissues using full spectrum flow cytometry
- Immunohistological staining and imaging of tissue sections using multiplexed immunohistochemistry
- Biochemical assays for cytokines and other inflammatory mediators
Collaborate closely with colleagues across disciplines to integrate findings into a comprehensive model of ageing
Analyze data, interpret results, and present conclusions through high-quality publications, presentations, and reports
Contribute to manuscript preparation
Participate actively in departmental seminars, workshops, and conferences

What we expect:

MSc degree in Biological Sciences
Strong background in immunology and/or ageing biology
Expertise in one or more of the following areas:
- Flow cytometry-based phenotyping and sorting
- Immunofluorescence microscopy and histopathological evaluation
- Statistical programming languages like R or Python
Excellent communication skills in English; proficiency in German desirable but not required
Willingness to work independently while contributing effectively to collaborative projects
Willingness to participate in ongoing training programs to enhance expertise and stay up to date with latest methodologies

What we offer:

Competitive salary according to TV-L E13 scale, initially limited to three years
Comprehensive benefits package including health insurance, pension plan, and family support services
Access to world-class infrastructure, equipment, and resources
Opportunities for professional growth, networking, and international collaboration
Supportive environment fostering creativity, innovation, and interdisciplinary exchange

BENEFITS

Exciting Projects
Professional Development and Training
Interdisciplinary Collaboration
Part of Research Innovation
Additional Benefits

For inquiries, please contact: Univ. Prof. Dr. Dr. Oliver Söhnlein, T 0251 83-53001

Apply now via our career portal until 16.04.2025 including:

Cover letter highlighting relevant experience, interests, and career goals (max. 2 pages)
Curriculum Vitae with publication list and academic record
Contact details for two referees familiar with your scientific achievements

(*gn=gender neutral)

The University Hospital of Münster is one of the leading hospitals in Germany. Such a position cannot be achieved by size and medical successes alone. The individual commitment counts above all. We need your commitment so that even with little things we can achieve great things for our patients. There are many possibilities open for you so that you may develop with them.

Universitätsklinikum Münster
Albert-Schweitzer-Campus 1, Gebäude D5
48149 Münster
www.ukm.de

Jetzt bewerben

Teilzeit , Befristete Anstellung

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Aktualisiert am 19.03.2025

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