Headerbild Department Internl Medicine III

PhD fellowship in translational fibrosis research / life sciences (E13, 65%, 3 years) (m/f/d)

Group/Department:
Group Translational Fibrosis Research, Dr. Christina Bergmann
Department Medicine 3, University Hospital Erlangen (Director: Prof. Dr. Georg Schett).

Tendering period:
15.01.2025 until 15.02.2025

Who we are:

We are an international and dynamic laboratory for translational tissue research. Our overarching aim is to delineate molecular mechanisms of tissue remodeling in fibrosing disorders as basis for novel therapeutic strategies. Systemic Sclerosis is our central model disease. We have a strong translational focus, which is also reflected in the tight collaboration of scientists and physician scientists within the group and the department of Medicine 3 (Prof. Schett). Group leaders have more than 10 years clinical and scientific experience in the field and we cooperate with national and international partners in academics.

The tasks:

We are looking for a highly motivated PhD student to work on a project focusing on mechanisms of tissue remodeling in Systemic Sclerosis as fibrosing model disease. Fibrosing diseases impose major socioeconomic burdens on modern societies and account for up to 45% of deaths in the developed world. Despite the huge medical need and first approved therapies the morbidity and mortality remain very high. New treatment options such as CD19.CART therapy offer new ways of deep immunosuppression. In this project we aim to characterize the mechanisms of tissue remodeling in different treatment options.

The student will work on established state-of the art techniques of molecular biology including immunofluorescence and histology, cell culture, RNA seq, Western blot, transfection and siRNA. The student will also be involved in establishing novel analysis and imaging methods. Working with mouse experiments is optional.

Expected Qualifications:

graduation at a Master´s level (or equivalent) in biological or biomedical sciences with convincing results
strong interest in biomedical research, to discover new fields and establish new protocols
strong interest to work both independently and co-operatively within an international research team
basic bioinformatic knowledge (e.g. usage of R)
good written and spoken English skills

We offer:

excellent resources including a fully-equipped laboratory for conducting experiments with state of the art in-vitro and in-vivo techniques of molecular biology
access to a variety of imaging modalities in the Optical Imaging Center Erlangen (OICE), access to core units next Next Generation Sequencing, imaging mass cytometry unit (CyTOF), among others
An empowering work environment embedded in the scientific infrastructure of the Department of Medicine 3 and University Hospital Erlangen (Head of Department: Prof. Schett)
Structured mentoring by experienced principal investigators and by the PI board of Medicine 3
Structured Graduation programs (email)
Interactions within a cooperative network in Department Medicine 3, Friedrich-Alexander Universität Erlangen and national and international cooperating partners

Contact person for questions and applications:

Dr. med. Christina Bergmann
Senior Physician
email

Jetzt bewerben

Vollzeit , Befristete Anstellung

Doktorandenstelle

Aktualisiert am 06.01.2025

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