About the Rudolf Virchow Center
The Rudolf Virchow Center at the University of Wuerzburg is a premier research institute dedicated to understanding the molecular mechanisms of cellular processes. Our center focuses on integrative and translational bioimaging, bridging the gap between basic research and clinical applications. We provide a vibrant scientific environment with access to cutting-edge technologies and collaborative research opportunities.
About the Position
The Kisker group from the Rudolf Virchow Center for Integrative and Translational Bioimaging at the University of Wuerzburg is seeking a highly motivated and talented PhD candidate to join our dynamic research team- This exciting project will focus on the structural biology of the FancJ helicase, an essential component in genome maintenance and DNA repair mechanisms, using cutting-edge cryo-electron microscopy (cryo-EM) techniques and biochemical analyses (see also reference).
PhD Position: Structural Studies on FancJ Helicase using Cryo-Electron Microscopy
Activities and responsibilities
Responsibilities:
- Conduct high-resolution structural studies of the FancJ helicase using cryo-EM.
- Prepare and optimize protein samples and cryo-EM grids.
- Collect and analyze cryo-EM data, including image processing and 3D reconstruction.
- Perform site directed mutagenesis and biochemical assays to investigate the functional implications of structural findings.
- Collaborate with interdisciplinary teams and contribute to the preparation of research manuscripts.
- Present findings at internal meetings, workshops and international conferences.
Reference:
Kuper, J., Hove, T., Maidl, S., Neitz, H., Sauer, F., Kempf, M., Schroeder, T., Greiter, E., Höbartner, C., & Kisker, C. (2024). XPD Stalled on Cross-Linked DNA Provides Insight into Damage Verification.
Nature Structural & Molecular Biology.
https://doi.org/10.1038/s41594-024-01323-5
Qualification profile
Qualifications:
- Master`s degree (or equivalent) in Biochemistry, Molecular Biology, Structural Biology or a related field.
- Strong background in protein biochemistry, including protein expression and purification.
- Experience with cryo-electron microscopy and structural biology is highly desirable.
- Proficiency in molecular biology techniques and mutagenesis.
- Excellent problem-solving skills and the ability to work independently as well as a part of the team.
- Strong communication skills and fluency in English, both written and spoken.
We offer
What we offer:
- Access to state-of-art cryo-EM facilities and equipment.
- A stimulating and collaborative research environment within a leading research institute.
- Opportunities for professional development, including training in advanced cryo-EM techniques and data analysis.
Competitive salary and benefits based on the German public salary scale (TV-L E 13; 65%).
Interested candidates should submit the following documents:
- A cover letter outlining your research interests and motivations for applying.
- A detailed CV, including a list of publications and presentations.
- Copies of academic transcripts and degree certificates.
- Contact information for at least two academic referees.
The JMU aims to reduce the underrepresentation of women and therefore explicitly encourages qualified women to apply.[1]
Severely handicapped applicants will be given preferential consideration in the case of broadly equal suitability, ability and professional achievements.
Please send your application as a single PDF file via
email The closing date for applications is 26th July 2024.
[1] Bei einer erheblichen Unterrepräsentation von Frauen ist eine besondere Aufforderung mit aufzunehmen.