The
Institute for Experimental Pediatric Hematology and Oncology at the Goethe-University Frankfurt (Director: Prof. Dr. Dirk Heckl) promotes translational cancer research. In particular, we study apoptosis signaling pathways in different malignancies in order to identify key targets for the development of new cancer therapeutics and novel prognostic biomarkers.
PhD student in Apoptosis Signaling, Senescence & Cancer
Activities and responsibilities
Apoptosis resistance is one of the hallmarks of cancer. It is regulated at the mitochondria by the B-Cell Lymphoma 2 (BCL2) protein family which orchestrate the release of cytochrome c from the mitochondria into the cytosol and the subsequent activation of caspases. BCL2, BCL-XL and MCL1 are frequently overexpressed in cancer and their role as important cellular oncogenes has been investigated in numerous studies. With the approval of Venetoclax, an anti-cancer therapeutic targeting BCL2, these BH3-mimetics have reached the clinic and are successfully used to treat leukemia. However, the BCL2 proteins and in particular BCL-XL, are also essential proteins in cellular senescence, and inhibition of BCL-XL has been shown to kill senescent cells.
The current project is led by PD Dr. Meike Vogler and funded by the José Carreras Leukämie-Stiftung. The research question will focus on the interactions between apoptosis and cellular senescence in aggressive lymphomas. In collaboration with Prof. Salvador Macip at the Josep Carreras Leukaemia Research Institute in Barcelona, we will investigate how BH3-mimetics may interfere with apoptosis induction and senescence. Successful applicants will join a supportive research team and will have the opportunity to participate in the International Graduate School in Biomedicine at Frankfurt and the German Cancer Consortium (DKTK).
Qualification profile
Interested candidates must have a M.Sc. or an equivalent degree in a relevant field. Applicants with skills in cell and molecular biology or experience in studying apoptosis are encouraged to apply. The ability to work successfully in a team and support fellow students, as well as good communication skills in English are essential for this collaborative research project. We are seeking candidates who are highly self-motivated to join a international and dynamic research team. The position can be filled immediately, initially for 3 years with the possibility for extension.
We offer
- A contract for 3 years (65% TV-L E13), with the possibility for extension
- A professional career development program for PhD students (GRADE)
- Implementation of your own ideas and working in an innovative, very well-equipped and scientifically stimulating environment with an innovative interdisciplinary team of highly motivated PhD students
- Co-supervision of Bachelor, Master and MD students
- Flexible working hours in order to achieve a positive work-life balance
- A job ticket for public transport in Frankfurt and the surrounding area
PD Dr. Meike Vogler
email