The Johann Wolfgang Goethe University Frankfurt is one of the largest universities in Germany with about 48,000 students and around 5,000 employees. Founded in 1914 by Frankfurt citizens and since 2008 back in the legal form of a foundation, the Goethe University has a high degree of autonomy, modernity and professional diversity. As a full-service university, the Goethe University Frankfurt offers more than 100 study programs on five campuses in a total of 16 faculties and at the same time has outstanding research strength.
Applications are invited for one
post-doctoral fellow position (m/f/d)
100%
(E13 TV-G-U)
available at the Institute of Cardiovascular Regeneration at the Goethe-University of Frankfurt (Germany).
We are embarking on an ambitious program to understand the molecular mechanisms and functional importance of immune cell disruption on cardiovascular health and disease. Our project aims to uncover the molecular mechanisms underlying the progression of aortic valve stenosis driven by clonal hematopoiesis mutations and to identify potential therapeutic targets.
The successful candidate will primarily engage in wet lab experiments, involving techniques such as single-cell RNA sequencing, targeted DNA sequencing, and various molecular biology methods to study immune cell behavior and signaling pathways in cardiovascular disease. Additionally, the candidate will assist with data analysis using computational tools.
Your role will be to utilize these approaches and to gain insights into fundamental drivers of disease.
We seek innovative, curious, and team-oriented researchers with a passion for cardioimmunology to join our team. We provide a highly stimulating, collaborative and international working environment with state-of-the-art infrastructure, and unique professional career development opportunities, with flexible scheduling and flexible off-site working.
The contract is initially limited to 2 years with the possibility of extension.
Postdoc (m/f/d)
Activities and responsibilities
our role:
- We are looking for applicants with background in cardiology, immunology, cellular biology or molecular biology. Experience in any of the following techniques is beneficial, but not mandatory: flow cytometry, protein expression assays (ELISAs, W. blot), cloning, histology, CRISPR/Cas9 gene editing, coculture or organoid model assays, cytokine profiling, single-cell RNA sequencing, or ATAC-seq.
- Develop and optimize additional experimental pipelines to enhance our understanding of cardiovascular disease mechanisms. Integrate wet lab results with bioinformatic analyses to generate comprehensive insights.
- Work closely with the principal investigator (PI), present findings at international conferences, publish results in peer-reviewed journals, and maintain professional networks. Assist with S1 documentation and ensure compliance with regulatory requirements.
Qualification profile
You have:
- A doctorate in molecular biology, biochemistry, genetics, immunology, or a related field.
- Extensive experience in wet lab techniques, including but not limited to cell culture, molecular cloning, sequencing technologies, histological analyses, protein expression, gene editing, and immunological assays. Basic proficiency in bioinformatics and programming languages such as R or Python for data analysis is advantageous.
- proficiency in German (C1) and excellent communication and presentation skills in English (primary communication will be in English).
- Organizational and team skills, flexibility, open-mindedness, good work ethic, positive attitude.
We offer
What we offer:
- International, diverse, and positive working atmosphere, flexible working environment.
- A competitive salary based on previous work experience, following the collective agreement applicable to the Goethe University.
- Access to state-of-the-art infrastructure.
- Professional career development opportunities and mentoring support.
- Landesticket Hessen, free use of public transportation in Hesse.
Interested candidates should send their application, consisting of a motivation letter, a CV, and the contact details of two/three previous advisors/mentors, as a single pdf to Prof. Dr. Wesley Abplanalp, Institute for Cardiovascular Regeneration, Center for Molecular Medicine, House 25B, Goethe University Frankfurt, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany, email
The University advocates equal rights for women and men and therefore strongly encourages women to apply. People with disabilities are given priority if they have the same qualifications.
Please do not submit any originals as the application documents cannot be returned. Travel and application costs cannot be reimbursed.
Prospective start date: as soon as possible