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PhD student (m/w/d)
Universitätsklinikum Heidelberg
Heidelberg, Baden-Württemberg
Molekularbiologie
Zellbiologie
Mikroskopie
Plasmodium
Malaria
wanted for April 1st 2025, at the Center for Infectious Diseases for the Parasitology department.
Investigating mechanisms of chromosome segregation during the exit of male Plasmodium gametes.
Malaria is a devastating infectious disease that kills more than half a million people per year. It is caused by the eukaryotic, single-celled parasite Plasmodium, which infects mosquitoes to spread from host to host. At the Hentzschel lab, we investigate the biology of early mosquito infection, particularly the formation of male gametes. This is a fascinating and extremely fast process that generates eight flagellated gametes from a precursor cell within only fifteen minutes (see examples of forming gametes on the right). Yet, the molecular mechanisms are not well understood, and how the parasite organises the segregation of eight genomes from a single nucleus into individual gametes remains elusive. We have previously identified an unusual protein complex that mediates DNA segregation during male gamete formation. We now want to understand the molecular and cellular processes underlying this phenotype, which might help to develop transmission-blocking drugs in the future.
What we offer
During your fully funded PhD project (3 years, 65 %) starting in April 2025, you will use state-of-the-art molecular biology, genetic engineering, structural biology and quantitative live-cell microscopy to investigate the activation, assembly and structure of the non-canonical Arp2/3 protein complex in the malaria parasite. The project is funded by an ERC Starting Grant and based on previous work of the lab (https://doi.org/10.21203/rs.3.rs-4479771/v1). You will join a dynamic group with plenty of opportunities to bring in your own ideas. You can expect a supportive environment and close mentoring with the aim to comprehensively expand your scientific and professional skills, enabling you to develop into an independent researcher. There will be opportunities to participate in international meetings to extend your scientific network and visibility in the field. Our lab is part of the Center for Infectious Diseases, located in the new CIID building on the Neuenheimer Feld Campus in Heidelberg, where you will have access to all necessary facilities and equipment. All PhD students at Heidelberg University are enrolled in graduate school offering many career development opportunities.
Investigating mechanisms of chromosome segregation during the exit of male Plasmodium gametes.
Malaria is a devastating infectious disease that kills more than half a million people per year. It is caused by the eukaryotic, single-celled parasite Plasmodium, which infects mosquitoes to spread from host to host. At the Hentzschel lab, we investigate the biology of early mosquito infection, particularly the formation of male gametes. This is a fascinating and extremely fast process that generates eight flagellated gametes from a precursor cell within only fifteen minutes (see examples of forming gametes on the right). Yet, the molecular mechanisms are not well understood, and how the parasite organises the segregation of eight genomes from a single nucleus into individual gametes remains elusive. We have previously identified an unusual protein complex that mediates DNA segregation during male gamete formation. We now want to understand the molecular and cellular processes underlying this phenotype, which might help to develop transmission-blocking drugs in the future.
What we offer
During your fully funded PhD project (3 years, 65 %) starting in April 2025, you will use state-of-the-art molecular biology, genetic engineering, structural biology and quantitative live-cell microscopy to investigate the activation, assembly and structure of the non-canonical Arp2/3 protein complex in the malaria parasite. The project is funded by an ERC Starting Grant and based on previous work of the lab (https://doi.org/10.21203/rs.3.rs-4479771/v1). You will join a dynamic group with plenty of opportunities to bring in your own ideas. You can expect a supportive environment and close mentoring with the aim to comprehensively expand your scientific and professional skills, enabling you to develop into an independent researcher. There will be opportunities to participate in international meetings to extend your scientific network and visibility in the field. Our lab is part of the Center for Infectious Diseases, located in the new CIID building on the Neuenheimer Feld Campus in Heidelberg, where you will have access to all necessary facilities and equipment. All PhD students at Heidelberg University are enrolled in graduate school offering many career development opportunities.
PhD student (m/w/d)
Activities and responsibilities
- Characterisation of rodent Plasmodium berghei parasites in mouse and mosquito vectors
- Cultivation of human-infecting Plasmodium falciparum parasites in cell culture (S2)
- Generation and characterisation of transgenic berghei and P. falciparum lines
- State-of-the-art widefield, confocal and super-resolution microscopy
- Preparation of scientific presentations and manuscripts for publication
Qualification profile
- Curiosity, passion and enthusiasm for unusual cell biology
- Master’s degree (or equivalent) in molecular biology or related disciplines
- Self-driven motivation, initiative and willingness to drive the project forward
- Ability to work both independently as well as collaboratively in a team
- Good communication skills in English (speaking, reading, writing)
- Willingness to work with experimental mouse models
- Prior experience with molecular biology essential, experience with Plasmodium desirable
We offer
- Goal-oriented, individual training and development opportunities (e.g. career courses offered by graduate school HBIGS)
- Working with the latest techniques / technical equipment state-of-the-art confocal and super-resolution microscopy
- Possibility to publish scientifically is offered and supported
- Regular team meetings
- Partial) project management / project responsibility possible if suitable
- Participation in national or international conference and collaboration
- Collectively agreed remuneration, attractive company pension scheme (VBL)
- 30 days vacation
- Sustainable travel: job ticket
- Family-friendly working environment: cooperative arrangements for childcare, subsidy for child vacation care, advice for employees with relatives in need of care
- Wide range of health, prevention and sports offers
For further information please contact Franziska Hentzschel via the apply button.
Interested?
Applications will be accepted until 31.01.2024 via the apply button
Part-Time
, Temporary
PhD Project
Updated at
10/31/2024
While applying for the job please refer to jobvector
Workplace
Job location
Im Neuenheimer Feld 672
69120 Heidelberg
Baden-Württemberg
Germany
Good to reach from...
- Karlsruhe
- Mannheim
- Ludwigshafen am Rhein
- Darmstadt
- Heilbronn
- Kaiserslautern
Salary
The stated amount is the estimated average gross annual salary for comparable full-time positions.
€ 51,296
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About Universitätsklinikum Heidelberg
Das Universitätsklinikum Heidelberg (UKHD) ist eines der bedeutendsten medizinischen Zentren in Deutschland und steht für die Entwicklung innovativer Diagnostik und Therapien sowie ihre rasche Umsetzung für den Patienten. Mit rund 14.000 Mitarbeitenden konzernweit in mehr als 50 klinischen Fachabteilungen mit über 2.500 Betten werden jährlich circa 80.000 Patienten voll-...
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